Thursday, October 26th: ABC...z Seminar Series: Probing biological systems in a new single-molecule regime

Event Date: 

Thursday, October 26, 2017 - 3:45pm

Event Date Details: 

Refreshments served at 3:30pm.

Event Location: 

  • Broida 1640
  • ABC...z Seminar Series

Investigating biological systems at the single-molecule level provides insights that are often not accessible through ensemble measurements. Such systems range from heterogeneous and dynamic processes to protein distribution and interaction in cells. In my talk I will discuss the development and application of novel technologies to study biological systems at a single-molecule level. I will start with a general introduction to quantum sensing, which recently has enabled the measurement of magnetic fields at a nanoscale. I will then show how we utilize such sensing techniques to control the temperature profile in living systems with subcellular resolution.  Furthermore, I will introduce a multicolor electron microscopy modality that can visualize the absolute location of proteins within the context of cellular ultrastructures with up to ten nanometer spatial resolution. Finally, I will provide an outlook on how quantum sensing and single-molecule biophysics can be utilized to perform nuclear magnetic resonance spectroscopy with unprecedented sensitivity, possible down to the level of individual biomolecules.

Peter Maurer, Stanford University