Thursday, Nov 30th: DNA origami: The bridge from bottom to tip

Event Date: 

Thursday, November 30, 2017 - 3:30pm

Event Date Details: 

Light refreshments served at 3:30 seminar begins at 3:45.

Event Location: 

  • Broida 1640
  • ABC...z Seminar Series

Conventional top-down nanofabrication, over the last six decades, has enabled almost all the complex electronic, optical and micro-fluidic devices that form the foundation of our society. Parallel efforts, exploring bottom-up self-assembly processes, have also enabled design and synthesis of structures like quantum dots, carbon nanotubes and unique bio-molecules that possess technologically relevant properties unachievable top-down. While both these approaches have independently matured, ongoing efforts to create “hybrid nanostructures” combining both strategies, has been fraught with technical challenges. The main roadblock is the absence of a scalable method to deterministically organize components built bottom-up within top-down nanofabricated structures. In this talk, I will first introduce a directed self-assembly technique that utilizes DNA origami1 as a molecular adaptor to modularly position, and orient, bottom-up nano-components (like quantum dots, light emitters and proteins) within top-down nanofabricated devices.2 I will then present experimental results demonstrating the utility of the technique to achieved absolute, arbitrarily scalable, control over the integration of discrete emitters inside optical devices.3,4 Finally, I conclude by presenting my vision of how DNA origami assisted modular bridge between top-down and bottom-up nanofabrication can enable a range of highly transformative, functional, devices. Specifically, I will discuss unpublished data demonstrating arrays of single-photon sources, platform for studying bio-chemical networks with discrete components and an integrated tool for real-time highly-multiplexed protein quantification.

Ashwin Gopinath, Caltech