CANCELED- Soft and Living Matter Seminar Series: Friday, March 13th, 2020 -- Glassy dynamics and memory effects in an intrinsically disordered protein

Event Date: 

Friday, March 13, 2020 - 1:30pm

Event Date Details: 

NOW CANCELED

Event Location: 

  • Elings 1601
  • Soft and Living Matter Seminar Series

CANCELED

 

Glassy, nonexponential relaxations in globular proteins are typically attributed to conformational behaviors that are missing from intrinsically disordered proteins. Yet, we show that single molecules of a disordered-protein construct display two signatures of glassy dynamics, logarithmic relaxations and a Kovacs memory effect, in response to changes in applied tension. We attribute this to the presence of multiple unknown local structures in the protein, which we corroborate with a model that correctly predicts the force-dependence of the relaxation. The relaxation mechanism reported here likely applies to other disordered proteins with local structure.